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The steroid hormone mechanism of action can be summarized as follows: Steroid hormones pass through the cell membrane of the target cell. The steroid hormone binds with a specific receptor in the cytoplasm. The receptor bound steroid hormone travels into the nucleus and binds to another specific receptor on the chromatin. The steroid hormones progestagens, estrogens, androgens, and glucocorticoids as well as their precursor cholesterol are required for successful establishment and maintenance of pregnancy and proper development of the fetus. The human placenta forms at the interface of maternal and fetal circulation. It acts as an estrogenic hormone receptor (ER) agonist and activator of PI 3-kinase

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